Προκήρυξη:
Applications for two fully funded PhD positions in collaboration with an industrial partner (EngD programme @ UCL Biochemical Engineering) are invited.
Selection criteria: Successful candidates will be based at the Department of Biochemical Engineering at UCL and spend part of their time with the industrial partner. Candidates should have a strong mathematical background (Engineering and/or Physics graduates) and a keen interest in Biology. Experience with computer programming and/or Matlab/Python are highly desired.
Brief description of the projects below.
For more information please contact alex.kiparissides@ucl.ac.uk
1. Development of an automated turbidostat platform for the investigation and characterization of the effects of environmental and process parameters on the physiology and metabolism of green algae. The aim of this project is to develop a defined, time invariant and highly controlled environment for the growth of microalgae. The EngD researcher will utilise Algenuity’s Algem® bioreactor platform in order to develop, implement, test and validate a turbidostat mode of operation. The developed platform will be used to conduct a detailed analysis of the impact of growth conditions, with a particular focus on light, on metabolism and cell physiology through a combined mathematical and experimental approach. For more information click here.
2. A framework for the development, analysis and validation of mathematical models of upstream unit operations used in the production of recombinant proteins as part of an integrated whole bioprocess modelling platform. The aim of this project is to develop a novel computational approach able to integrate, organize and guide experimental information across multiple scales and unit operations in order to enable “whole bioprocess” simulation and optimization studies. The developed models will be experimentally validated and will be used to derive optimal fed-batch feeding strategies (through model based optimization) and, subsequently, to implement these strategies at the bioreactor scale. The EngD researcher will utilise the gPROMS® family of products for the development of mathematical models and will focus on their “plugand-play” integration within PSE’s whole bioprocess modelling platform. For more information click here.