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Χρηματοδοτούμενη θέση για μεταδιδακτορική έρευνα στη Νευροανοσολογία στο Ελληνικό Ινστιτούτο Παστέρ

Προκήρυξη:

Postdoctoral Position in Neuroimmunology
Laboratory of Molecular Genetics
Hellenic Pasteur Institute, Athens, Greece

Position available:
The Laboratory of Molecular Genetics at the Hellenic Pasteur Institute in Athens is looking to recruit a post-doctoral researcher, who is interested in investigating the regulation of phagocyte effector functions in inflammatory demyelinating disease of the CNS such as multiple sclerosis. Previous work shows that the microglial cells and their products (TNF, IL- 1β) are key effectors of cognition and brain surveillance in the healthy brain while at the same time contribute to pathology, by enhancing the inflammatory response to animal models of demyelination. The proposed project aims to study the contribution of two specific microglial targets, the microglial transcription factor NF-κB and the two-pore domain potassium channel THIK-1, to the development and progression of pathology using two well established models of MS, experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination, and develop novel transgenic and in vivo imaging tools to track their phenotypes and effector functions in vivo.
The project is financed by a grant from the Hellenic Foundation for Research and Innovation (ELIDEK, for more information see http://www.elidek.gr/en/homepage/) and headed by Dr Vasiliki Kyrargyri, who has recently arrived in Athens from UCL in London for this purpose, and involves international collaborations. If successful, the project will extend for up to a total of 3 years.

Job requirements:
We are seeking to recruit a highly motivated, enthusiastic and hard-working applicant with a deep understanding of microglia/macrophage biology and general neuroimmunology. The candidate should have experience with MS models (EAE and/or Cuprizone), transgenic mouse lines, primary immune cell based assays, flow cytometry, immune-histopathology, confocal imaging and molecular techniques. Experience in the intravital two-photon imaging, image processing and MATLAB will be a plus. The successful candidate is expected to have strong skills in English, and to have a demonstrated scientific track record, including at least one first author publication in a peer review scientific journal within a relevant field. The successful candidate should be able to work independently and responsibly, to critically analyse data, prepare and communicate results, prepare manuscripts and publish research findings in high quality journals. The position will provide excellent training in many aspects of demyelination and animal models of multiple sclerosis, as well as, opportunities to join international meetings and visit international labs for training.
If you are interested in this position please send a letter of motivation, your CV and the names and contact details of 2 to 3 references to:

Dr Vasiliki Kyrargyri
Email: v.kyrargyri@ucl.ac.uk
Selected recent relative publications from us:
Madry et al., PNAS, 13:1608-1617 (2018)
Madry et al., Neuron, 17:299-312 (2018)
Karamita et al., JCI insight, 2(8):87455 (2017)
Kyrargyri et al., Glia, 63:549-66 (2015)


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