The ARCH (Age-Related Changes in Hematopoiesis) Project is a network of highly qualified experts in experimental hematology created to decipher the causal relationship between the physiological changes in the hematopoietic system during lifespan and the parallel occurrence of specific age-related hematological diseases (pediatric, adult, elderly), with the aim of developing novel targeted therapeutic treatments. ARCH research will integrate the results from complementary model systems (cell lines, mouse models, cells from leukemia patients) and will deploy a large panel of cutting-edge technologies, such as single cell genomics, epigenomics, genome editing and organoid cultures, in a multi-faceted effort. The ARCH ambitious goal requires scientific and financial resources beyond the capability of a single group. To reach this goal, the ARCH network brings together 15 beneficiaries (12 academic, 2 SMEs and 1 private research institute) and 5 Partner organisations (3 academic, 1 SME and 1 patients’ association). Two European Consortia are present through their Italian nodes.
ARCH will recruit 15 Early Stage Researchers (ESRs) who will be all enrolled in PhD programmes. Besides research laboratory work, the ARCH training programme includes scientific, technical and transferable skills courses that will provide ESRs with a solid scientific culture and with awareness of responsible research and innovation issues. The unique combination of scientific excellence, quality of the educational programme and experience in translating basic research into exploitable results will provide ARCH with the real possibility of positively contributing to the enhancement of European competitiveness in the development of innovative, targeted drugs/treatments for hematological diseases, which currently represent a serious socio-economical problem for the European health care system.
The project will be coordinated by Prof. Antonella Ronchi at the University of Milano-Bicocca – Department of Biotechnology and Biosciences (Italy).
The ARCH consortium involves 15 Beneficiaries recruiting the ESR. The 15 Positions are listed here below and you can find more details in ARCH website https://arch-project.eu/.
ESR 1 - Università Degli Studi Di Milano-Bicocca (Italy)
Identification of Sox6 and NR2F2 downstream networks controlling normal (and malignant) erythropoiesis
ESR2 - Academisch Ziekenhuis Groningen (Netherlands)
Physiological HSCs changes during ageing
ESR3 - Centre Européen De Recherche En Biologie Et Médecine (France)
Defining the function of the Helios transcription factor in hematopoietic stem cell ageing
ESR4 - King's College London (United Kingdom)
Investigating the role of defective DNA repair mechanisms in HSC aging
ESR5 - Flowmetric Europe Spa (Italy)
Dissecting human hematopoietic differentiation by polychromatic flow cytometry and single cell transcriptome analysis
ESR 6 - Università Degli Studi Di Roma La Sapienza (Italy)
Defining the role of N6-methyladenosine (m6A) in AML cell differentiation
ESR 7 - Veterinaermedizinische Universitaet Wien (Austria)
Identification of critical effectors of oncoproteins in acute leukemia
ESR 8 - Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften (Germany)
The aged dormant HSC compartment under homeostatic and stressed conditions
ESR 9 - Institut National De La Santé Et De La Recherche Médicale (France)
Characterization of a new epigenetic marker in AML cells
ESR 10 - Agencia Estatal Consejo Superior De Investigaciones Cientificas(Spain)
Genetic analysis of PRC1 function in homeostatic and malignant hematopoiesis
ESR 11 - Institut Curie (France)
Hijacking developmental pathways as therapeutic targets in T-cell acute lymphoblastic leukemia (T-ALL)
ESR 12 - Tel Aviv University (Israel)
Modeling the role of the thymic stromal lymphopoietin (TSLP) receptor and TSLP in Acute Lymphoblastic Leukemia (ALL)
ESR 13 - Fondazione M. Tettamanti E Menotti De Marchi Onlus (Italy)
Modeling the development and sustainment of pre-leukemia and leukemia target treatment
ESR 14 - Diagenode (Belgium)
Highlighting epigenomics in MLL-rearranged AML
ESR 15 - Idryma Iatroviologikon Ereunon Akademias Athinon (Greece)
The role of STAT5 target gene networks in leukemia
The Marie Skłodowska-Curie programme offers highly competitive and attractive salary and working conditions. Exact salary will be confirmed upon appointment. In particular it consists of:
- a monthly living allowance: 3,270 euro/month (€39,240/year); this amount is then adjusted through the application of a country correction coefficient to the living allowance of the country in which the researcher is recruited: 106.7% to Austria, 100.0% to Belgium, 115.7% to France, 97% to Germany, 88.7% to Greece, 104.4% to Italy, 107.9% to Netherlands, 139.8% to United Kingdom, 95.4 % to Spain, 106.1% to Israel
- a monthly mobility allowance: 600 euro/month
- a monthly family allowance, if applicable depending on the family situation: 500 euro/month.
It must be noted that the living allowance is a gross EU contribution to the salary costs of the researcher. Consequently, the net salary results from deducting all compulsory (employer/employee) social security contributions as well as direct taxes (e.g. income tax) from the gross amounts. The rate indicated here is for researchers devoting themselves to their project on a full-time basis.
The mobility and family allowance is a fixed amount, regardless of the country of recruitment, and may be taxable depending on the country in which the researcher is recruited.
For more details please see Sections 5.1, 5.2 and 5.3 of the Guide for Applicants to H2020-MSCA-ITN-2018.
Who can apply
Applicants need to fully comply with the following eligibility criteria:
- Applicants must be Early-Stage Researchers (ESRs) who, at the time of recruitment by the host, are in the first four years (full-time equivalent) of their research careers. This is measured from the date when they obtained the degree which formally entitles them to embark on a doctorate.
- Applicants cannot already hold a PhD.
- Applicants can be of any nationality. They are required to undertake physical, transnational mobility: they must not have resided or carried out their main activity in the country of the host institute for more than 12 months in the last three years immediately prior to the reference recruitment date. In the case of researchers with refugee status, they will benefit from a less restrictive mobility rule;
- Applicants must be proficient in both written and spoken English.
Applicants for ARCH have to meet the following main criteria:
- Excellent Master’s degree or equivalent qualification in an area relevant to the main scientific themes/objectives/activities of the ARCH Project
- Strong evidence of genuine interest and motivation in scientific research
- Excellent references
- Publications in a relevant research field are desirable
How to apply
Please visit ARCH website https://arch-project.eu/ for information on the application procedure and requirements.
The deadline for application is September 15th 2019.
ARCH Project pursues a policy of equal opportunities: amongst equally qualified candidates, care will be taken to ensure gender balance and to recruit researchers from European countries where research is less advanced and/or between Refugees.